GAME OVER is the story of gamer fighting demons inside her and also in the outside world. In December 2017, in Sector 101 in Gurugram, a young girl named Amruta (Sanchana Natarajan) is stalked by an unknown killer while she’s enjoying her meal in her house, all alone. Sometime later, the killer enters her house, assaults her and takes her out of the house in a football field. Here, he beheads her and sets her body on fire. A year later, Sapna (Taapsee Pannu), who stays in Dhankot in Gurugram is having a traumatic time. She is a video game designer and a video game addict who stays alone in a palatial house along with her house help Kalamma (Vinodhini Vaidyanathan). A couple of weeks after Amrutha was murdered, Sapna too had a harrowing time, on New Year’s Eve, when she was raped and the whole act was filmed. With December 31 approaching, she begins to have panic attacks. Since the rape, she has not been able to stay in darkness for more than few seconds. In the midst, she begins to face a new problem. She has a game-centric tattoo on her wrist and it begins to ache badly. Before going to the skin specialist, she goes to the tattoo artist Varsha (Ramya Subramanian) to check if it’s something to do with the tattoo. Varsha hesitatingly informs her that she had mistakenly put a memorial tattoo on Sapna. Meaning, a small amount of ash, of Amrutha, was mixed in the tattoo ink. It was to be used for the tattoo of Amrutha’s mother Dr. Reema (Parvathi T) but by mistake, it was applied on Sapna. Sapna is obviously aghast on knowing this information. She attempts to kill herself but survives. After a meeting with Dr. Reema and knowing the kind of fighter Amrutha was, Sapna decides to start life afresh. At this point, however, the killer who killed Amrutha begins to stalk Sapna. On December 31, he decides to murder her. What happens next forms the rest of the film.